position effect

position effect
Effect on the expression of a gene depending upon its position relative to other genes on the chromosome. Moving (transposing) a gene from an inactive region to an active region can alter expression markedly - sometimes with unfortunate consequences as with the Philadelphia chromosome abnormality that leads to CML.

Dictionary of molecular biology. 2004.

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  • Position effect — is the effect on the expression of a gene when its location in a chromosome is changed, often by translocation. This has been well described in Drosophila with respect to eye color and is known as position effect variegation (PEV). [cite journal… …   Wikipedia

  • position effect — position effect. См. эффект положения. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • position effect — padėties efektas statusas T sritis augalininkystė apibrėžtis Genų veiklos priklausymas nuo erdvinio jų išsidėstymo. atitikmenys: angl. position effect rus. эффект положения …   Žemės ūkio augalų selekcijos ir sėklininkystės terminų žodynas

  • Position-effect variegation — is a variegation caused by the inactivation of a gene in some cells through its abnormal juxtaposition with heterochromatin.The classical example is the Drosophila w [m4] (speak white mottled 4) translocation. In this mutation, an inversion on… …   Wikipedia

  • Position effect variegation — Die Positionseffekt Variegation (PEV) ist ein Phänomen in der Genetik. Inhaltsverzeichnis 1 Entdeckung 2 Siehe auch 3 Einzelnachweise 4 Literatur // …   Deutsch Wikipedia

  • position effect — noun (genetics) the effect on the expression of a gene that is produced by changing its location in a chromosome • Topics: ↑genetics, ↑genetic science • Hypernyms: ↑consequence, ↑effect, ↑outcome, ↑ …   Useful english dictionary

  • position effect — noun Date: 1930 a genetic effect in which the expression of a gene is influenced by its interaction with usually adjacent genes and which is modified when the spatial relationships of the genes change (as by translocation) …   New Collegiate Dictionary

  • position effect — The influence of the location of a gene (particularly a transgene) on its expression and hence its effect on phenotype …   Glossary of Biotechnology

  • position effect — The difference in the phenotypic expression of a gene due to a change in their position with respect to other genes on the chromosome …   Dictionary of invertebrate zoology

  • position effect — in genetics, the change in expression of a gene as a function of a change in its position relative to that of other genes …   Medical dictionary

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